Peptides are protein molecules no more than 1 nm in size . They regulate cell metabolism, intercellular interactions.
The interfering peptide interferes with the interaction between the D1 and D2 dopamine receptors in the brain. It has antidepressant properties equal to that of imipramine. The delivery of the peptide to the brain is carried out using a pressurized intranasal system from Impel Neuro Pharma . The dosage is 1.67 nmol / g. The effect occurs 2 hours after administration. The target of the drug is the prefrontal cortex. New treatments for depression will soon supersede pharmacotherapy based on the administration of an active substance through the digestive tract or intravenously. In addition to intranasal administration of an interfering peptide, new treatments for depression include:
- Focused ultrasound;
- infrared light therapy;
- low frequency magnetic stimulation (LFMS);
- optogenetic stimulation.
Unfortunately, in Russia, modern methods of treating depression are not available to most patients and are implemented only within the framework of a private psychiatric service.